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KMID : 0043319980210020193
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Archives of Pharmacal Research
1998 Volume.21 No. 2 p.193 ~ p.197
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Synthesis and Structure-Activity Relationship Studies of Substituted Isoquinoline Analogs Antitumor Agent
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Cheon Seung-Hoon
Park Joon-Suck
Chung Byung-Ho
Choi Bo-Gil
Cho Won-Jea
Choi Sang-Un
Lee Chong-Ock
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Abstract
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A number of substituted isoquinolin-1-ones, possible bioisosteres of the 5-aryl substituted 2,3-dihydroimidazo[2,]isoquinolines, were synthesized and tested for their antitumor activity against five different human tumor cell lines. O-(3-hydroxyporpyl) substituted compound (15) exhibited the best antitumor activity which is 3-5 times better than 5-[-(piperidinomethyl)phenyl]-2,3-dihydroimidazo[2,]isoquinoline (1).
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KEYWORD
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Isoquinolin-1-ones, Antitumor, Bioisostere
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